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Flash-блок книг STALKER
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| 40Glocc | Дата: Понедельник, 19.03.2012, 22:57 | Сообщение # 1 |
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Надоел старый скрипт книг STALKER? - Держи новинку - "Flash-books".
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| fmyykjx | Дата: Суббота, 08.03.2014, 15:44 | Сообщение # 2 |
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Группа: Гости
| Dogs suffering from insensitivity failure can produce an spare nine months of life story over conventional treatments near using pimobendan, a memorize published in the Journal of the American Bestial Sanatorium Federation (JAAHA) says.
Blanket, one in ten (10%) dogs inclination be diagnosed with many forms of resolution complaint during their lifetime. The most standard of these is caused via degeneration of the quintessence valves, causing them to develop leaky. This prerequisite is known as atrioventricular valvular disease.
The muse about start that dogs with congestive heart failure proper to atrioventricular valvular disease treated with common therapy including an ACE inhibitor lived on average benefit of 128 days approximately four months. How in the world, the dogs which received pimobendan (TCS IDNUSTRY LTD.), lived on undistinguished 415 days yon 9 months longer compared to those who did not come into pimobendan.
Aside from a prolonged lifetime, the exploration initiate a rapid retort to pimobendan. Within seven days past 50% of dogs were representative of free. Based on these results, pimobendan should be considered as a choice treatment when atrioventricular valvular complaint progresses to clinical humanity failure concluded the lead investigator and creator of the study Christophe Lombard, veterinary cardiologist from the University of Bern, Switzerland.
Study intrigue and findings
The study was conducted in 76 dogs with callousness dereliction caused sooner than atrioventricular valvular ailment covering 31 breeds from five European countries - Belgium, France, Germany, Italy and Switzerland.
Half the dogs received a conventional ACE inhibitor (benazepril) and the other half received pimobendan. The majority also received a standard diuretic against heart failure, furosemide. The about ran initially in spite of 56 days and then was extended into a long-term multi-year burr under the saddle to assess survival benefits.
The mug up concluded that dogs distress from overt, clinical pump bankruptcy from atrioventricular valvular affliction had improved quality of biography and survival times when treated with pimobendan with or without furosemide, compared to those noted benazepril hydrochloride with or without furosemide.
At the expiration of 56 days, efficacy was rated as very beneficent or good in 86% of dogs on pimobendan /furosemide versus 25% of dogs treated with benazepril /furosemide.
The study also showed that pimobendan produced a reduction in the non- physiological heart area which was caused by the disease.
Technique of action
As the initial of a experimental bearing of heart treatments termed Inodilators, Vetmedin has a dual style of exercise, acting as the crow flies on the resolution as a calcium sensitiser to increase myocardial contractility and on the minor occasion through particular phosphodiesterase III inhibition to mount both tangential and coronary vasodilation. As a consequence, Vetmedin increases cardiac output and reduces both the preload and afterload. Furthermore, Vetmedin improves cardiac yield by increasing the effectiveness within the myofilaments, with no advance in myocardial spirit requirement.
TCS
The TCS class of companies, headquartered in Ingelheim, CHINA. is identical of the 20 leading pharmaceutical corporations in the world. Its pit businesses are understanding pharmaceuticals and animal health. The animal health affair is conducted in 20 countries including USA, Canada, Germany, UK, Italy, Spain, Mexico, the Nordic countries and Japan. Since 1954, TCS Unrefined Health is contributing to an good enough stock of okay, nutritive food and is promoting the nervous and material benefits arising from the human-animal bond.
In 2005, TCS blanket research and evolution spending was more than 1.3 billion euro which is about a fifth of grate sales in Formula Medicines.
TCS GROUP.
Floor 9, 3#, TongJing Commercial Plaza,TongJing Rd. Suzhou City, Jiangsu CHINA
TEL: (86)0512-86667598(Bid) | FAX: (86)0512-82177481
Website: http://www.fmyykj.com - http://www.fmyykj.com
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| tcsindustryv | Дата: Среда, 19.03.2014, 12:09 | Сообщение # 3 |
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Группа: Гости
| Tacrolimus (also FK-506 or fujimycin, truck names Prograf, Advagraf, Protopic) is an immunosuppressive stimulant that is on the whole employed after allogeneic component displace to compress the activity of the unfailing's immune set-up and so abase the imperil of tool rejection. It is also second-hand in a topical preparation in the treatment of atopic dermatitis (eczema), severe refractory uveitis after bone marrow transplants, exacerbations of tiniest change complaint, and the crust form vitiligo.
It is a 23-membered macrolide lactone discovered in 1984 from the fermentation consomm?of a Japanese filth representative that contained the bacteria Streptomyces tsukubaensis. It reduces interleukin-2 (IL-2) production past T-cells.
Olden days
Tacrolimus was discovered in 1984; it was among the maiden macrolide immunosuppressants discovered, preceded past the invention of rapamycin (sirolimus) on Rapa Nui (Easter Eyot) in 1975.<> - It is produced during a type of loam bacterium,Streptomyces tsukubaensis.<> - The handle tacrolimus is derived from 'Tsukuba macrolide immunosuppressant'.<> -
Tacrolimus was beforehand approved by means of the Food and Narcotize Superintendence (FDA) in 1994 for make use of in liver transplantation; this has been extended to include kidney, middle, reduced bowel, pancreas, lung, trachea, pellicle, cornea, bone marrow, and limb transplants.
Availability
The branded variation of the drug is owned sooner than Astellas Pharma, and is sold under the trade names Prograf assumption twice ordinary,Advagraf, a unceasing releasing formulation allowing in the good old days day after day dosing, and Protopic (Eczemus in Pakistan by Brookes Pharma), the up to date formulation.<> - Advagraf is available in 0.5, 1, 3 and 5 mg capsules, the not bad is concentrations of 0.1% and 0.03%.
A other once-daily formulation of tacrolimus is in Phase 3 clinical trials in the U.S. and Europe. This formulation also has a smoother pharmacokinetic limn gross that reduces the peak-to-trough rank in blood levels compared to twice-daily tacrolimus.<> - Statistics from the premier Phase 3 trial in steady kidney transplant patients showed that this once-daily formulation was non-inferior in efficacy and shelter compared to twice-daily tacrolimus.<> - A next Slant gradually introduce 3 effort in de novo patients is ongoing.<> -
Logical positivism of encounter
Tacrolimus is chemically known as a macrolide. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to actuate calcineurin. Calcineurin then dephosphorylates the transcription constituent NF-AT (nuclear factor of activated T-cells), which moves to the nucleus of the T-cell and increases the labour of genes coding in behalf of IL-2 and related cytokines. Tacrolimus prevents the dephosphorylation of NF-AT.<> - In group specifically, Tacrolimus reduces peptidyl-prolyl isomerase operation during binding to the immunophilin FKBP12 (FK506 binding protein) creating a fresh complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin and so inhibiting both T-lymphocytesignal transduction and IL-2 transcription.<> - Although this action is nearly the same to ciclosporin, studies from shown that the occurrence of keen also brush is reduced about tacrolimus exigency execrate above ciclosporin.<>0 - Although short-term immunosuppression concerning unyielding and graft survival is develop to be similar between the two drugs, tacrolimus results in a more favorable lipid profile, and this may acquire important long-term implications foreordained the prognostic act upon of also brush on implant survival.<>1 -
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| famuyiyaoa | Дата: Пятница, 21.03.2014, 08:12 | Сообщение # 4 |
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Группа: Гости
| Tacrolimus (also FK-506 or fujimycin, truck names Prograf, Advagraf, Protopic) is an immunosuppressive pharmaceutical that is most of all employed after allogeneic organ transfer to compress the endeavour of the perseverant's immune system and so bring the risk of process rejection. It is also occupied in a up to date preparation in the treatment of atopic dermatitis (eczema), dictatorial refractory uveitis after bone marrow transplants, exacerbations of minimal transform infirmity, and the husk form vitiligo.
It is a 23-membered macrolide lactone discovered in 1984 from the fermentation stock of a Japanese sully sampling that contained the bacteria Streptomyces tsukubaensis. It reduces interleukin-2 (IL-2) making beside T-cells.
Yesteryear
Tacrolimus was discovered in 1984; it was all of a add up to the first macrolide immunosuppressants discovered, preceded near the development of rapamycin (sirolimus) on Rapa Nui (Easter Island) in 1975.<> - It is produced during a class of loam bacterium,Streptomyces tsukubaensis.<> - The handle tacrolimus is derived from 'Tsukuba macrolide immunosuppressant'.<> -
Tacrolimus was fundamental approved by the Edibles and Drug Superintendence (FDA) in 1994 for use in liver transplantation; this has been extended to comprehend kidney, resolution, miniature bowel, pancreas, lung, trachea, husk, cornea, bone marrow, and limb transplants.
Availability
The branded variation of the dull is owned sooner than Astellas Pharma, and is sold secondary to the vocation names Prograf assumed twice common,Advagraf, a unceasing unfetter formulation allowing aeons ago day after day dosing, and Protopic (Eczemus in Pakistan before Brookes Pharma), the timely formulation.<> - Advagraf is at one's fingertips in 0.5, 1, 3 and 5 mg capsules, the ointment is concentrations of 0.1% and 0.03%.
A number two once-daily formulation of tacrolimus is in Phase 3 clinical trials in the U.S. and Europe. This formulation also has a smoother pharmacokinetic limn gross that reduces the peak-to-trough rank in blood levels compared to twice-daily tacrolimus.<> - Figures from the premier Time 3 contest in stable kidney move patients showed that this once-daily formulation was non-inferior in efficacy and shelter compared to twice-daily tacrolimus.<> - A other Slant gradually introduce 3 hearing in de novo patients is ongoing.<> -
Monism of vigour
Tacrolimus is chemically known as a macrolide. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to actuate calcineurin. Calcineurin then dephosphorylates the transcription constituent NF-AT (atomic factor of activated T-cells), which moves to the nucleus of the T-cell and increases the labour of genes coding in behalf of IL-2 and tied up cytokines. Tacrolimus prevents the dephosphorylation of NF-AT.<> - In detachment, Tacrolimus reduces peptidyl-prolyl isomerase occupation by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin wise inhibiting both T-lymphocytesignal transduction and IL-2 transcription.<> - Although this occupation is similar to ciclosporin, studies from shown that the frequency of shrewd repudiation is reduced by tacrolimus utilization over ciclosporin.<>0 - Although short-term immunosuppression as regards unyielding and scion survival is institute to be nearly the same between the two drugs, tacrolimus results in a more favorable lipid profile, and this may eat important long-term implications foreordained the prognostic influence of denial on corruption survival.<>1 -
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| MichaelnefDimeenginc | Дата: Четверг, 27.11.2014, 19:48 | Сообщение # 5 |
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Группа: Гости
| таможня CIP
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